If instead of a wrinkle itself, we have a fold in that area caused by a fall in the tissues that originates as a surplus of skin under the corners of the lip, we must treat it in another way. In this case, the fold in the marionette line is the symptom but not the problem, the problem is the flaccidity of the tissues that has caused that fold, so that where we must attack is that problem of flaccidity. The correct procedure will be to regenerate collagen at the level of the middle third of the face to reposition the skin that has descended to the lower third, for this we will use collagen regenerating fillers, tensor threads or facial radiofrequency.